The same holds true for peptide lip treatments, a category of lip products that gained attention. But how peptide lip helps your lips?

The 7 Best Peptide Lip Treatments for Plump Lips

Peptides have become a hot topic of discussion lately, and it’s no wonder why. Whether found in a peptide eye cream or serum, this ingredient is known for its ability to plump, firm, and stimulate collagen production like no other. The same holds true for peptide lip treatments, a category of lip products that gained attention thanks to Hailey Bieber’s Rhode brand. But what exactly are peptides? And how peptide lip helps your lips?

According to Dr. Gendai Echezona, a triple board-certified physician and owner of Premier Pain Care & Wellness, peptides play a crucial role in various biological processes. They have garnered interest in skincare due to their potential anti-aging and skin-repairing properties. When it comes to the lips, peptides are becoming popular for their ability to enhance collagen, provide hydration, and repair damage.

In simpler terms, peptides can help keep the lips moisturized and prevent chapping, similar to a lip balm. Additionally, Dr. Mona Foad, a board-certified dermatologist and founder of Mona Dermatology, explains that certain peptides can stimulate collagen production in the lips, resulting in improved firmness and volume. This leads to the desired fuller look, and some peptide lip treatments can even serve as lip gloss or lip masks. According to Dr. Azadeh Shirazi, a board-certified dermatologist at La Jolla Laser Dermatology and founder of AziMD Skincare, anyone can benefit from peptide lip treatments as they typically have no side effects and are gentle on the skin, causing no irritation.

We want only the best to touch your lips, which is why we consulted our experts, tested a few ourselves, and researched countless formulas to compile this list of the 7 best peptide lip treatments. Once you try one, you’ll never want to be without it.

Peptide Lip Treatment

Rhode Peptide Lip Treatment

$16 at

  • Doubles as a gloss
  • Non-sticky
  • May need to reapply throughout the day

Perhaps the most famous peptide lip treatment, Rhode’s iteration has it all: hydrating ingredients, a plumping effect, and a glossy finish. “It’s formulated with shea butter to nourish the lips and peptides to plump and support lip collagen, and its rich texture helps hydrate and protect dry lips,” raves Dr. Shirazi.

Key ingredients: Peptides, shea butter, cupuaçu, babassu

Size: 0.3 fl oz.

Rhode rating: 4.4/5 stars

An ELLE editor says: “Due to some unreasonable stubbornness, I refused to try this product for a while—it couldn’t be that good, right? Well, I’m here to tell you that it actually is that good. Even without any other product underneath, my lips somehow look fuller after a layer of the Rhode Peptide Lip Treatment. I also love how glossy it is without being sticky (I cannot deal with a sticky gloss), and I adore every single tinted version of the formula.” —Carol Lee, associate beauty e-commerce writer

The PLASMA Lip Compound

U Beauty The PLASMA Lip Compound

$68 at

  • Appears to erase fine lines
  • Variety of shades
  • Pricey

Beyond the clear original shade, this option from U Beauty boasts 12 other gorgeous hues in the range, including champagne coral and deep chocolate. The formula also helps smooth texture over time with chemical exfoliants.

Key ingredients: Peptides, ceramides, alpha hydroxy acid, poly-hydroxy acid, salicylic acid, shea butter, beeswax

Size: 0.51 fl. oz.

U Beauty rating: 4/5 stars

A U Beauty reviewer says: “I am a lip gloss/lip balm fanatic, and U Beauty Plasma Lip is hands down the best one out there. It not only nourishes your lips but also plumps without the annoying tingle. I keep one in my bathroom, one in my car, and one in my purse.”

Wet Lip Oil Gloss

Kosas Wet Lip Oil Gloss

$22 at

  • Variety of shades
  • Non-sticky
  • Some reviewers reported leaky packaging

This easy-to-apply gloss is a true delight for your lips; it’s bursting with nourishing ingredients like hyaluronic acid and avocado oil to glaze your lips and leave them healthy-looking, plump, and soft. Apply a sheer wash of it on its own or over a lipstick or lip liner to get a more pigmented, punchy effect.

Key ingredients: Peptides, hyaluronic acid, evening primrose oil, avocado oil, konjac root, shea butter

Size: 0.15 oz.

Kosas rating: 4.5/5 stars

A Kosas reviewer says: “I have never liked anything on my lips, but I absolutely love this! It feels as nourishing as the best lip balm you can find but a gorgeous color!”

Pout Preserve Peptide Lip Treatment

OLEHENRIKSEN Pout Preserve Peptide Lip Treatment

$22 at Ulta Beauty

  • Clinically tested
  • Some may dislike scents

“The Olehenriksen Pout Preserve Peptide Lip Treatment contains peptides, natural moisturizers, and antioxidants that nourish, hydrate, and protect the lips, thus enhancing the appearance of the lips,” says Dr. Echezona. The three scents are a real treat, too: citrus, cocoa, and strawberry sorbet.

Key ingredients: Peptides, mango seed butter, cloudberry oil

Size: 0.4 oz.

Ulta rating: 4.6/5 stars

An Ulta reviewer says: “This is definitely my new go to for fixing dry, cracked, chapped lips. Will definitely be getting another one in the near future for my office.”

ORMEDIC Balancing Lip Enhancement Complex

IMAGE Skincare ORMEDIC Balancing Lip Enhancement Complex

$25 at Dermstore

  • Non-sticky
  • Glossy
  • On the pricier side

Dry lips don’t stand a chance against this peptide lip treatment. It contains hard-hitting moisturizing ingredients like peptides, avocado oil, and vitamin E. Applying a thin layer during the day and a thicker one at night will allow your pout to stay happy, healthy, and plump.

Key ingredients: Peptides, vitamin E, avocado oil

Size: 0.25 oz.

Dermstore rating: 4.8/5 stars

A Dermstore reviewer says: “I have extremely chapped lips. Most lip balms and other lip products just make my lips peel more. This one actually keeps my lips hydrated and lets them heal. Expensive but worth it.”

Instant FIRMx Lip Treatment

Peter Thomas Roth Instant FIRMx Lip Treatment

$29 at Dermstore

  • Plumping
  • Some reviewers reported leaky packaging
  • On the pricier side

While there are a lot of topical “lip filler” or “lip plumping” products out there that’ll sting and irritate your lips, the most you’ll feel with this one is a slight tingle. The formula both creates a temporary plumping effect and encourages a fuller look with consistent use over time.

Key ingredients: Peptides, hyaluronic acid

Size: 0.3 oz.

Sephora rating: 4.2/5 stars

A Sephora reviewer says: “Guys, it actually works! I applied it at the beginning of the week, and three days later, my lips definitely feel plumper and hydrated for sure. The weather became drastically colder, and I noticed that my little lines are less visible than usual too.”

Cold Plasma Plus+ Lip Therapy

Perricone MD Cold Plasma Plus+ Lip Therapy

$32 at Dermstore

  • Airtight packaging
  • Nourishing
  • Pricey

As we age and our lips lose volume, we may often see more fine lines and wrinkles on and around our mouths. This Perricone MD fights those signs of aging with the help of peptides, hyaluronic acid, and omegas, and it doubles as a lipstick primer. Plus, a few swipes can reduce bleeding and feathering.

Key ingredients: Peptides, hyaluronic acid, omegas

Size: 0.15 oz.

Dermstore rating: 4.6/5 stars

A Dermstore reviewer says: “This cleared up dry flaky spots that had existed for over ten years. I’ve used Perricone for around twenty years and continue to be pleased with the outcome of each and every product I try. It’s worth every penny. At 62, I face new makeup challenges as never before. With these products, and a 10X magnification mirror, I can continue my makeup routine…”


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